Fig. 2 | Scientific Reports

Fig. 2

From: Application of Brucella type IV secretion proteins VirB1, VirB5, and VirB6 in the serological diagnosis of brucellosis

Fig. 2

IELISA Analysis of Human Serum Samples. (A) Dot plot of human serum samples showing optical density (OD) values from the indirect ELISA. Positive samples are in red, and negative samples are in blue. The cut-off value (dashed line) is determined using the Youden index from the ROC analysis. (B) ROC analysis of human serum samples illustrates the diagnostic performance of recombinant VirB proteins, with AUC values of 0.9948 for rVirB1, 0.9855 for rVirB5, and 0.9808 for rVirB6. The ROC curve demonstrates high sensitivity and specificity in distinguishing positive from negative samples, with the cut-off value marked and sensitivity and specificity values listed in the table below.

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