Fig. 3 | Scientific Reports

Fig. 3

From: Enhancement of doxorubicin efficacy by diosmetin through DNA damage accumulation and P-glycoprotein inhibition in breast cancer cells

Fig. 3

DNA damage induced by DT, DOX and both simultaneously detected by the neutral comet assay in MCF-7 cells. (a) Representative micrographs of comet assay results. MCF-7 cells were treated with 1 µM DOX or 80 µM DT and combined for 48 h, control cultures were treated with DMSO (0.5%) as a vehicle (acquired at 100x and 200x magnification). (b) Representative graph obtained by plotting the means of tail length and tail moment (c). The values are presented as the mean of three independent experiments ± SD. 100 individual cells were selected for calculations. DOX doxorubicin, DT diosmetin,DT + DOX diosmetin + doxorubicin.

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