Table 2 Epitope characterization table.
Epitopes table | ||||
|---|---|---|---|---|
Protein | Sequence | Polyprotein Position | Structural context | Role in viral replication |
C | INRWGSVGKKEAMEI | 97–111 | Positively charged helix/loop | RNA packaging; nucleocapsid assembly |
E | GSLVTCAKFACSKKM | 432–446 | Exposed helix or connecting loop | Membrane fusion during host cell entry |
E | CSKKMTGKSIQPENL | 442–456 | Surface-exposed loop | Involved in conformational changes during fusion |
E | CRLKMDKLRLKGVSY | 612–626 | C-terminal domain, transmembrane-associated | Virion assembly and envelope stabilization |
E | DKLRLKGVSYSLCTA | 617–631 | Transmembrane anchor region | Envelope protein membrane anchoring |
NS1 | LPHGWKAWGKSYFVR | 936–950 | Central α-helix or β-sheet | Immune evasion; replication complex formation |
NS1 | KAWGKSYFVRAAKTN | 941–955 | Surface loop | Host interaction; modulation of immune response |
NS5 | ETLGEKWKARLNQMS | 2557–2571 | Central RdRp helix | Genomic RNA synthesis (RNA-dependent RNA polymerase activity) |
NS5 | KKQGEFGKAKGSRAI | 3012–3026 | C-terminal basic-rich region | Nuclear transport; host interaction; replication regulation |
