Fig. 7 | Scientific Reports

Fig. 7

From: MOF enhances the sensitivity and selectivity of sorafenib as an anticancer drug against hepatocellular carcinoma and colorectal cancer in vitro

Fig. 7

Schematic representation of the apoptotic activity and cell cycle profile of nanocomposite IC50 after treatment for 24 h on the HepG2 cancer cell line. (A and B) Apoptosis activity; (A) Annexin V/PI (untreated control); (B) Annexin V/PI (treated with 23.49 µg/ml SOR-MIL-53). The right lower quadrant represents annexin V positive/PI negative staining, indicating early apoptosis. The right upper quadrant represents both high annexin V and PI staining, indicating late apoptosis, and the left upper quadrant represents low annexin V and high PI staining, indicating necrosis. (C and D) Cell cycle profile; (C) cell count in the cell cycle stages (untreated control), (D) cell count in the cell cycle stages (treated with 23.49 µg/ml SOR-MIL-53).

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