Fig. 1 | Scientific Reports

Fig. 1

From: Amitriptyline inhibits bronchoconstriction independent of direct receptor binding and reduces number of caveolae

Fig. 1

Illustration of signaling pathways leading to airway smooth muscle contraction. Classical pathways via PLC-PKC and RhoA/ROCK together with alternative pathways via different calcium channels in the plasma membrane and caveolae. ACh, acetylcholine; 5-HT, 5-hydroxytryptamine; ET-1, endothelin; PM, plasma membrane; DAG, diacylglycerol; GPCR, G protein-coupled receptors; IP3, inositol trisphosphate; IP3R, IP3 receptor; LVGC, L-type voltage-gated Ca2 + channel; MLCK, myosin light chain kinase; MLCP, myosin light chain phosphatase; PIP2, phosphatidylinositol 4,5-bisphosphate; PKC, protein kinase C; PLC, phospholipase C; rMLC, regulatory myosin light chain; ROCK, Rho kinase; RyR, ryanodine receptor; SR, sarcoplasmic reticulum.

Back to article page