Fig. 4
Amitriptyline reduces number of caveolae comparable to MBCD. (A-C) Transmission electron microscopy images of airway smooth muscle cells of rats derived from PCLS, without treatment (A), with MBCD (3.2 mM) (B) and amitriptyline (1 µM) (C). The black arrows point to typical caveolae. (D) Number of intact caveolae per 10µm2 after MBCD (3.2 mM) and amitriptyline (1 µM) treatment. All graphs represent means ± SEM; *** p ≤ 0.001. n = 3 in all groups. Up to three slices per condition were measured for each animal.
