Fig. 5 | Scientific Reports

Fig. 5

From: Amitriptyline inhibits bronchoconstriction independent of direct receptor binding and reduces number of caveolae

Fig. 5

The inhibitory effect of amitriptyline on bronchoconstriction is independent of cholesterol-lowering mechanisms or actin (de)polymerization. (A–E) Concentration–response curves of rat PCLS stimulated with acetylcholine and pretreated with 1 µM amitriptyline and 3.2 mM MBCD (A), 3.2 mM MBCD, 6.5 µM cholesterol, 1 µM amitriptyline (B), 1 µm amitriptyline,10 µM simvastatin for 24 h (C) or 72 h (D) or 10 µM cyclocalasin D, 1 µM amitriptyline and combinations (E).

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