Fig. 7
Effects of α2-AdR antagonists on DA-induced inhibitory action. A: The α2-AdR antagonist RS79948 significantly reduced the DA-induced inhibitory action when analyzing all obtained data (n = 21). Right: Distribution of eEPSC amplitudes after 5-7 min of DA application. B: Twelve out of 21 data showed a clear inhibitory effect on deep cerebellar nuclei neurons (filled circles, n = 12). This suggests that DA acted on expressed DA receptors, as shown in the schematic drawing (right). In 9 out of 21 data, DA application had no observable effect (open circles, n = 9). These results suggest that D2-like receptors were heterogeneously expressed in certain synapses of the deep cerebellar nuclei, as shown in the schematic drawing under the condition of α2-AdR blockade.
