Fig. 5 | Scientific Reports

Fig. 5

From: Astaxanthin mitigates cardiac toxicity induced via doxorubicin by alleviating mitochondrial fission and autophagy in rats

Fig. 5

Astaxanthin exhibits inhibitory effects on DOX-induced cardiac mitochondrial autophagy. (A) WB bands of mitochondrial autophagy-associated proteins ULK1, Parkin, Beclin-1,PINK1, P62, and LC3. (B-G) WB analysis data of ULK1, Parkin and PINK1, P62, LC3 and Beclin-1 were obtained. ASTA reduces the expression of ULK1, Parkin, Beclin-1and PINK1, lowers the ratio of LC3II to LC3I, and increases the expression of P62, suggesting that astaxanthin can alleviate cardiac mitochondrial autophagy induced by DOX. The measurement data were presented as mean ± standard deviation, n = 6, *P value < 0.05. ns: no significance. DOX: Doxorubicin; ASTA: Astaxanthin; ULK1: Unc-51 Like Autophagy Activating Kinase 1; PINK1: PTEN-Induced Putative Kinase 1; Parkin: Parkin RBR E3 Ubiquitin Protein Ligase; P62: Sequestosome 1; LC3: Microtubule-Associated Proteins 1 A/1B Light Chain 3.

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