Table 4 Multivariate analysis was conducted to examine disease-free survival and overall survival in MBC patients.

From: Evaluation of serum alkaline phosphatase and lactate dehydrogenase as predictive biomarkers for the prognosis of male breast cancer

Variable

DFSa

OS

HR (95%CI)

P value

HR (95%CI)

P value

Score of “joint score”

Good

1 (Reference)

1 (Reference)

Intermediate

3.169 (1.426–8.187)

0.009

6.211 (2.330-13.313)

< 0.001

Poor

6.947 (2.300–12.796)

0.002

13.109(4.094–1.450)

< 0.001

Age, y

< 66

1 (Reference)

1 (Reference)

≥ 66

0.578 (0.220–1.520)

0.267

0.648 (0.255–1.647)

0.362

BMI, kg/m2

< 24

1 (Reference)

1 (Reference)

≥ 24

0.977 (0.367–2.599)

0.962

1.592(0.618–4.101)

0.336

T stage

T1

1 (Reference)

1 (Reference)

T2

1.229 (0.368–4.105)

0.737

1.657 (0.217–3.992)

0.458

T3

1.153 (0.256–5.190)

0.853

1.656 (0.160–3.692)

0.558

T4

1.530 (0.279–8.389)

0.624

3.782 (0.186–7.595)

0.724

N stage

N0

1 (Reference)

1 (Reference)

N1

3.205 (1.922–7.654)

0.003

1.928 (0.555–6.695)

0.052

N2

4.545 (1.136–18.182)

0.032

2.807 (0.991–8.303)

0.301

N3

6.451(0.572–28.991)

0.300

4.007 (0.572–17.533)

0.563

Molecular type

Luminal A

1 (Reference)

1 (Reference)

Luminal B

0.734 (0.167–3.232)

0.682

1.600 (0.83–3.56)

0.500

HER2 over-expression

2.072 (0.352–9.367)

0.795

2.567 (0.909–6.992)

0.790

Triple negative

1.892 (0.246–14.544)

0.540

3.088 (0.772–13.916)

0.696

  1. DFS, disease-free survival; OS, overall survival; BMI, body mass index; HER-2, human epidermal growth factor receptor 2.
  2. aTwelve patients (15.0%) underwent biopsies without subsequent surgical intervention. Thus, these individuals were excluded from the analysis of DFS.
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