Fig. 3
Calculations of the interaction among integrins, talin, and membranes in the formation of nascent adhesions. (A) Force vs. extension responses with respect to inputs in Fig. S3. The extension of the crosslinker was defined from its fixed point (red bead) to the maximum \({M}_{c}\) point on the membrane (black bead). Expanded views of indicated regions (arrows) are provided in Fig. S5. (B, C) Half-max \({M}_{c}\) area vs. extension responses for the crosslinkers. (D‒F) Deformed shapes of the membrane-crosslinker complex. The data point index is indicated at the top. Surface maps indicate the membrane strain \(\alpha\) and the sum of normalized elastic modulus densities at the top and bottom, respectively. See Fig. S4 for the membrane-crosslinker complex from a different viewpoint. See Fig. S6 for the surface map of \({M}_{c}\) for \(c=1\) and \(c=2\). See Fig. S15 for the degrees of freedom. See Movie S2 for all membrane-crosslinker configurations used in the analyses in this figure.
