Fig. 1 | Scientific Reports

Fig. 1

From: Overexpression of alcohol dehydrogenase 1 A inhibits the progress of triple negative breast cancer via Wnt/β-catenin signaling

Fig. 1

Identification of Tyrosine Metabolism Genes Influencing TNBC Prognosis. (A) Volcano plot depicting differentially expressed genes (DEGs) in the TCGA-TNBC cohort. (B) KEGG pathway enrichment analysis for both upregulated and downregulated DEGs. KEGG pathway map adapted from Kanehisa et al. (KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27–30). Kanehisa Laboratories. Used with permission. (C) Identification of 14 tyrosine metabolism-related genes (TRGs). LogFC (Log Fold Change) represents the expression ratio of a specific gene in tumor tissue relative to normal tissue. (D) Consensus clustering cumulative distribution function (CDF) for k 2 to 4. (E) Relative change in area under the CDF curve for k 2 to 4. (F) Consensus clustering matrix for k = 2. (G) Kaplan-Meier overall survival curves for the two clusters.

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