Fig. 2
Cross-bridge scheme. Sites on the thin filament switch between states that are available (Non) and unavailable (Noff) for cross-bridges to bind to. Myosin heads transition between a super-relaxed detached state (MSRX), a disordered-relaxed detached state (MDRX), and a single attached force-generating state (MFG). J terms indicate fluxes between different states. Reproduced with permission from Springer Nature from Sharifi et al.28.
