Fig. 1

Multimodal imaging of New Zealand White (NZW) and Dutch-belted (DB) Rabbit retina: (A and E) Color fundus photography image of NZW (A) and DB (E) rabbits, respectively. These images clearly show morphology of retinal vessels (RVs), nerve fiber layer (NFL), choroidal vessels (CVs), retinal pigment epithelium (RPE), and optic nerve (white dotted circles). (B and F) Fundus autofluorescence images showing healthy retina without any evidence of RPE atrophy. (C and G) Fluorescein angiography of NZW and DB, respectively. (D and H) Indocyanine green angiography images clearly show structure of the choroidal vessels. (I and J) B-scan spectral domain OCT (SD-OCT) images demonstrating the cross section retina constructed from different layers such as inner limiting membrane (ILM), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor layer (PL), choroid layer (CL), and sclera. The OCT scan region of interest is indicated by scanning lines (SL) and marks as red dotted lines overlay on the fundus photographs (a and d), corresponding to the rabbit’s visual streak. This region was chosen for its high photoreceptor density and relevance to retinal function as a structure akin to the human macula.