Fig. 6 | Scientific Reports

Fig. 6

From: Nandrolone alters the behavioral response to cocaine as well as striatal and cortical dopamine receptors of prepubertal male rats

Fig. 6

D2DR in the mPFC and NAc of rats exposed to nandrolone during postnatal days 28–37 and tested for behavioral sensitization. A and C: Nandrolone did not affect D2DR expression in the mPFC. However, a decrease in D2DR expression in the mPFC was observed in animals treated with cocaine. B and D: In contrast, nandrolone treatment increased D2DR expression in the NAc and, similar to what was observed in the PFC, cocaine reduced D2DR in the NAc. Data are presented as mean ± SEM (n = 4). Representative western blots of D2DR and B-Actin in the mPFC (A) and NAc (B) of rats exposed to nandrolone during postnatal days 28–37,  tested for behavioral sensitization and sacrificed on PN 63. Data were analyzed using One-Way ANOVA. Western blots images were cropped for publishing purposes; replicates are included as Supplementary Material.

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