Fig. 7

Conditioned Place Preference to cocaine of rats exposed to nandrolone during postnatal days 28–37. Male rats were injected daily from PN 28–37 with nandrolone (20 mg/kg) or sesame oil and tested for CPP to cocaine from PN 40–53. Nandrolone-treated males showed a decrease in the time spent in the chamber associated with cocaine compared to oil-treated males. During the postconditioning test, nandrolone-treated rats spent 48% of their time in the chamber associated with cocaine compared to 70% spent by oil-treated males. Rats injected with saline did not show a change in the time spent in the chamber where they were injected with saline. Although oil and nandrolone-treated males were conditioned to cocaine, conditioning was more robust in Oil-treated males. Data are presented as mean ± SEM (n = 8) and analyzed by a Two Way ANOVA (See supplementary material for detailed statistical analysis).