Fig. 8 | Scientific Reports

Fig. 8

From: Nandrolone alters the behavioral response to cocaine as well as striatal and cortical dopamine receptors of prepubertal male rats

Fig. 8

D2DR in the mPFC and NAc of rats exposed to nandrolone during postnatal days 28–37 and tested for CPP. Representative western blots of D2DR and B-Actin in the mPFC (A) and NAc (B) of rats exposed to nandrolone during postnatal days 28–37, tested for CPP and sacrificed on PN 53. B and D: Nandrolone increased D2DR expression in the mPFC and NAc of prepubertal rats. Fig. 6B and D: In contrast, cocaine decreased D2DR expression in both brain areas (mPFC and NAc), similar to what was observed in brains obtained from animals that were tested for behavioral sensitization and killed at a later age, day 64 (Fig. 6B and D). Data are presented as mean ± SEM (n = 4) and analyzed using One-Way ANOVA. Western blots images were cropped for publishing purposes; replicates are included as Supplementary Material.

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