Fig. 6 | Scientific Reports

Fig. 6

From: Epigenomic profiling of immune cell subtypes reveals H3K27ac-marked stress signatures after long-duration spaceflight

Fig. 6

Prolonged orbital spaceflight induces changes in H3K27ac in in CD8+ and CD4+ immune cells at regions linked to diverse cellular signalling pathways. (a and b) Gene-set-enrichment analysis for peaks with differential H3K27ac signal in CD8+ (a) CD4+ (b) immune cells following prolonged orbital spaceflight. Analysis was performed for GO biological process pathways using ChIP-Enrich. All significantly enriched pathways (FDR ≤ 0.05) were categorised into non-immune-associated pathways and further subcategorised using REVIGO. Abbreviations: dev: development, diff: differentiation, neg: negative, reg: regulation.

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