Fig. 2

Forest Plot Showing the Results of a Secondary Analysis in Cytotoxic Drug Users. (a) Serum Sodium Levels (b) BUN Levels. Serum sodium concentrations were categorized into three groups based on reference values: “Low level” (<138 mmol/L), “Normal range” (138–145 mmol/L), and “High level” (>145 mmol/L). BUN levels were categorized into three groups based on clinical reference values: low (<8 mg/dL), normal (8–20 mg/dL), and high (>20 mg/dL). Crude odds ratios for the occurrence of UAC were calculated by comparing each group to a combination of the other two. The comparisons were as follows: “Low level” vs. (“Normal range” + “High level”),“Normal range” vs. (“Low level” + “High level”), and “High level” vs. (“Low level” + “Normal range”). UAC, unplanned acute care; CI, confidence interval; BUN, blood urea nitrogen. (c) BUN/CRE Ratio The BUN/CRE ratio, an indicator of dehydration, was analyzed to assess its association with the occurrence of UAC in cytotoxic drug users. Ratios were divided into two categories: BUN/CRE<20 and BUN/CRE ≥20. Crude odds ratios were calculated to compare the risk of UAC between the two groups. UAC, unplanned acute care; CI, confidence interval; BUN, blood urea nitrogen; CRE, creatinine.