Fig. 3

Forest Plot Showing the Results of a Secondary Analysis among Molecular-targeted Drug Users. (a) CRE. Blood creatinine levels were categorized into three groups based on sex-specific reference values: “Low level” (men: CRE < 0.65 mg/dL, women: CRE < 0.46 mg/dL), “Normal range” (men: 0.65 ≤ CRE ≤ 1.07 mg/dL, women: 0.46 ≤ CRE ≤ 0.79 mg/dL), and “High level” (men: CRE > 1.07 mg/dL, women: CRE > 0.79 mg/dL). Crude odds ratios for the occurrence of UAC were calculated by comparing each group to a combination of the other two. (b) eGFR. Patients were divided into two groups based on eGFR levels: <45 mL/min/1.73 m² (more than moderate renal function decline) and ≥ 45 mL/min/1.73 m² (less than moderate renal function decline). Crude odds ratios for the occurrence of UAC were calculated for these categories. UAC, unplanned acute care; CI, confidence interval; CRE, creatinine; eGFR, estimated glomerular filtration rate.