Table 3 Frequency of the most commonly reported adverse drug reactions (ADRs) by treatment group and symptom category.

From: Effectiveness and safety of escitalopram treatment personalized based on therapeutic drug monitoring of drug plasma concentration: a prospective cohort study

Adverse drug reactions (ADRs)

Entire cohort

Inadequate drug level

Unadjusted dose

Adjusted dose

Autonomous nervous system

Dry mouth

11/60

2/13

2/19

7/60

Increased sweating

5/92

0/13

0/19

5/60

Central nervous system

Sedation

7/92

0/13

0/19

7/60

Increased dreaming

6/92

0/13

0/19

6/60

Fatigue

4/92

0/13

0/19

4/60

Headache

1/92

0/13

0/19

1/60

Gastrointestinal

Diarrhea

5/92

1/13

1/19

3/60

Nausea

4/92

2/13

0/19

2/60

Sexual dysfunctions

Decreased libido

12/92

3/13

3/19

6/60

Anorgasmia

9/61

1/9

3/13

5/39

Dry vagina

5/61

0/9

3/13

2/39

Ejaculatory dysfunction

11/31

3/4

3/6

5/21

Erectile dysfunction

3/31

1/4

0/6

2/21

  1. Sexual dysfunction items were evaluated by sex: “Decreased libido” in both sexes; “Anorgasmia” and “Dry vagina” in females (n = 61); “Ejaculatory dysfunction” and “Erectile dysfunction” in males (n = 31).
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