Fig. 4 | Scientific Reports

Fig. 4

From: Integrated systems biology reveals an 8-gene signature predicting early-stage lung adenocarcinoma progression and patient survival

Fig. 4

Survival analysis reveals association between SAS-module eigengene values and overall survival in lung cancer. (A) Two anti-correlated modules (M3 and M6) driving opposing genetic SAS-module signatures were selected for survival analysis. The M3 module was positively associated with OS and while the M6 module was negatively associated with a death event (OS). Kaplan–Meier (KM) survival analysis significantly distinguished patients separated by high and low module expression in all SAS-modules. The red line in each Kaplan–Meier plot represents survival of cases in the higher expression tier and the black line represents survival in cases with lower expression. A Wald test determined p-values and hazard ratio HR scores with 95% CIs. (B) Significantly higher survival with lower expression was seen in all M3 differentially expressed hub genes (MYBL2 p < 0.0001, HR = 2.28, CI = 1.49–2.49; KIF4A p = 0.00085, HR = 1.67, CI = 1.23–2.27; RRM2 p < 0.0001, HR = 2.24, CI = 1.65–3.05; DEPDC1 p < 0.0001, HR = 2.07, CI = 1.49–2.87; ANLN p < 0.0001, HR = 2.52, CI = 1.85–3.42).

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