Table 2 Ontology enrichment modules for MEs of interest with correlation to survival or staging clinical traits.

Turquoise

M1

p = 0.013

RNA splicing

0.03019598

Staging/survival

mRNA processing

0.03019598

Blue

M2

NS

Regulation of nucleobase-containing compound metabolic process

5.45E−50

Survival

Regulation of RNA metabolic process

5.45E−50

Regulation of RNA biosynthetic process

4.26E−46

Regulation of DNA-templated transcription

8.54E−46

Regulation of transcription by RNA polymerase Ii

1.15E−39

Brown

M3

p = 0.0083

Cell cycle

4.74E−64

Staging/survival

Cell cycle process

5.98E−60

Nucleobase-containing compound metabolic process

1.90E−54

Nucleic acid metabolic process

1.94E−53

Mitotic cell cycle

7.83E−50

Yellow

M4

NS

Macromolecule metabolic process

1.11E−10

Survival

Nucleic acid metabolic process

1.73E−09

Primary metabolic process

1.28E−08

Nucleobase-containing compound metabolic process

2.89E−08

Organic substance metabolic process

7.08E−08

Green

M5

NS

Immune system process

4.67E−63

Staging

Defense response

2.73E−61

Immune response

1.80E−53

Response to external stimulus

4.11E−52

Regulation of immune system process

1.18E−49

Red

M6

p = 0.00039

Lipid metabolic process

3.04E−06

Staging/survival

Surfactant homeostasis

5.74E−4

Chemical homeostasis

1.59E−3

Fluid transport

3.78E−3

Monoatomic ion transmembrane transport

4.19E−3

Black

M7

NS

Oxidative phosphorylation

2.30E−35

Staging/survival

Mitochondrial translation

3.16E−30

Aerobic respiration

3.73E−30

Cellular respiration

2.24E−29

Atp synthesis coupled electron transport

1.90E−28

Pink

M8

NS

Anatomical structure morphogenesis

1.47E−51

NA

Extracellular structure organization

5.06E−48

External encapsulating structure organization

5.06E−48

Extracellular matrix organization

5.06E−48

System development

2.44E−43

Magenta

M9

p = 0.042

Immune system process

6.14E−83

Staging/survival

Immune response

2.70E−76

Regulation of immune system process

1.85E−51

Regulation of immune response

3.39E−44

Positive regulation of immune system process

8.12E−42

Purple

M10

NS

Vasculature development

3.03E−32

Staging

Blood vessel development

6.68E−31

System development

2.56E−28

Circulatory system development

5.78E−28

Anatomical structure morphogenesis

6.22E−28

Greenyellow

M11

NS

Nucleic acid metabolic process

2.97E−4

Staging/survival

Regulation of cellular process

5.17E−4

Regulation of transcription elongation by Rna polymerase Ii

5.17E−4

Rna metabolic process

1.08E−3

Regulation of Dna-templated transcription elongation

1.16E−3

Tan

M12

NS

No significant biological processes associated

NS

Staging

Salmon

M13

NS

Macromolecule metabolic process

4.60E−4

NA

Protein metabolic process

3.18E−2

Protein transport

3.77E−2

Primary metabolic process

3.92E−2

Organic substance metabolic process

4.76E−2

Cyan

M14

NS

Cellular respiration

2.59E−3

NA

Mitochondrial respiratory chain complex assembly

2.59E−3

Mitochondrion organization

2.59E−3

Generation of precursor metabolites and energy

1.13E−2

Aerobic respiration

1.17E−2

Midnightblue

M15

NS

Rna metabolic process

9.85E−3

NA

Regulation of nucleobase-containing compound metabolic process

1.44E−2

Regulation of Rna metabolic process

1.85E−2

Positive regulation of biosynthetic process

1.85E−2

Nucleobase-containing compound transport

2.02E−2

Lightcyan

M16

p = 0.0086

Adaptive immune response

9.87E−157

Staging

Immune response

1.52E−108

Immune system process

5.36E−86

Immunoglobulin mediated immune response

3.43E−78

B cell mediated immunity

2.09E−77

Grey60

M17

NS

Cytoplasmic translation

2.61E−120

NA

Translation

7.12E−85

Organonitrogen compound biosynthetic process

1.64E−55

Gene expression

1.51E−39

Macromolecule biosynthetic process

1.14E−34

Lightgreen

M18

NS

No significant biological processes associated

NS

Staging