Table 4 Grade assessment using GRADEpro.
From: Correlation between allergy and cancer: a systematic review and meta-analysis
Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
№ of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | intervention | comparison | Relative (95% CI) | Absolute (95% CI) | ||
Colorectum cancer | ||||||||||||
17 | non-randomised studies | not serious | not serious | not serious | not serious | none | 5,193,460 cases 4,945,128 controls | OR 0.82 (0.76 to 0.89) | ⨁⨁◯◯Low | IMPORTANT | ||
- | 48.0% | 49 fewer per 1,000 (from 68 to 29 fewer) | ||||||||||
Breast cancer | ||||||||||||
13 | non-randomised studies | not serious | not serious | not serious | not serious | none | 7692 cases 9021 controls | OR 0.97 (0.89 to 1.05) | - | ⨁⨁◯◯ Low | IMPORTANT | |
- | 54.0% | 8 fewer per 1,000 (from 29 fewer to 12 more) | ||||||||||
Lymphoma | ||||||||||||
13 | non-randomised studies | not serious | not serious | not serious | not serious | none | 6970 cases 92,248 controls | OR 0.85 (0.79 to 0.92) | - | ⨁⨁◯◯ Low | IMPORTANT | |
- | 93.0% | 11 fewer per 1,000 (from 17 to 6 fewer) | ||||||||||
Pancreatic cancer | ||||||||||||
12 | non-randomised studies | not serious | seriousa | not serious | not serious | none | 5,178,044 cases 4,910,516 controls | OR 0.75 (0.69 to 0.82) | - | ⨁◯◯◯ Very lowa | IMPORTANT | |
- | 48.0% | 71 fewer per 1,000 (from 91 to 49 fewer) | ||||||||||
Lung cancer | ||||||||||||
10 | non-randomised studies | not serious | seriousa | not serious | not serious | none | 928 cases 3132 controls | OR 0.99 (0.82 to 1.19) | - | ⨁◯◯◯ Very lowa | NOT IMPORTANT | |
- | 77.0% | 2 fewer per 1,000 (from 37 fewer to 29 more) | ||||||||||
Prostate cancer | ||||||||||||
9 | non-randomised studies | not serious | not serious | not serious | not serious | none | 2254 cases 3899 controls | OR 1.07 (0.98 to 1.17) | - | ⨁⨁◯◯ Low | IMPORTANT | |
- | 63.0% | 16 more per 1,000 (from 5 fewer to 36 more) | ||||||||||
Leukemia | ||||||||||||
8 | non-randomised studies | not serious | seriousa | not serious | not serious | none | 3170 cases 84,258 controls | OR 0.48 (0.34 to 0.66) | - | ⨁◯◯◯ Very lowa | IMPORTANT | |
- | 96.0% | 40 fewer per 1,000 (from 69 to 19 fewer) | ||||||||||
Brain Cancer | ||||||||||||
8 | non-randomised studies | not serious | not serious | not serious | not serious | none | 5108 cases 10,017 controls | OR 0.77 (0.73 to 0.82) | - | ⨁⨁◯◯ Low | IMPORTANT | |
- | 66.0% | 61 fewer per 1,000 (from 74 to 46 fewer) | ||||||||||
Gastrointestinal cancers | ||||||||||||
7 | non-randomised studies | not serious | seriousa | not serious | not serious | none | 5,129,173 cases 4,773,524 controls | OR 0.84 (0.52 to 1.37) | - | ⨁◯◯◯ Very lowa | NOT IMPORTANT | |
- | 48.0% | 43 fewer per 1,000 (from 156 fewer to 78 more) | ||||||||||
Gynecological cancers | ||||||||||||
7 | non-randomised studies | not serious | not serious | not serious | not serious | none | 4513 cases 6413 controls | OR 0.87 (0.69 to 1.10) | - | ⨁⨁◯◯ Low | IMPORTANT | |
- | 59.0% | 34 fewer per 1,000 (from 92 fewer to 23 more) | ||||||||||
