Fig. 1

Induction of the model And division of groups And group treatment. 5× 10⁵ CT26 cells were inoculated subcutaneously into the right flank of the mice. On day 7 after inoculation, the mice were randomly divided into 8 groups, with 6 mice in each group. Nanoliposomes containing 5FU And DA were injected intravenously into the mice 4 times as shown in the figure. Finally, the mice were sacrificed three days after the last injection to examine gene expression, and a number of mice were also kept for survival.