Fig. 6

Relative abundance profile of the vaginal microbiota between the group with HPV persistent-positive (HPV_PP) and the group with HPV turn-negative (HPV_TN). (a) Principal component analysis (PCA) of the genital tract microbiota based on the bacterial operational taxonomic units (OTUs) between the HPV_PP and HPV_TN groups. (b) Anosim analysis of the microbial beta diversity vaginal microbiota based on the OTUs between the HPV_PP and HPV_TN. (c) Differentially expressed vaginal microbiota between the HPV_PP and HPV_TN groups chosen by |LDA score| > 2 and P < 0.05. (d) Cladogram showing the most differentially abundant taxa identified by LEfSe between the HPV_PP and HPV_TN groups. (e) Receiver operating characteristic (ROC) curves of the likelihood of persistent HPV infection predicted by the relative abundance of Prevotella bivia and Anaerococcus prevotii.