Fig. 3

ROC curves for differentiating AQP4-IgG+ON from other ON-related CNS diseases (MOG-IgG+ON, MS-ON, and ION), based on standardized cpRNFL thickness, ONH-MV, ONH-MT, and peripapillary choroidal MBR. The AUC was 0.739 (95% CI 0.574–0.903; P = 0.086) for OCT alone (cpRNFL thickness; blue), and 0.873 (95% CI 0.772–0.974; P < 0.001) for LSFG parameters alone (red). When cpRNFL thickness and LSFG parameters were combined (black), the AUC reached 0.892 (95% CI 0.764–0.999; P < 0.001).