Fig. 1 | Scientific Reports

Fig. 1

From: PD-L1 autoregulation promotes the proliferation, migration and invasion of glioblastoma cells via GP130/JAK2/STAT3/IRAK2/IL6 signaling pathway

Fig. 1The alternative text for this image may have been generated using AI.

PD-L1 mRNA expression was elevated and positively associated with poor survival of patients with GBM. (A) Expression of PD-L1 RNA in human GBM tissues and normal brain tissue in TCGA-GBM dataset analyzed by using GEPIA online tool. (B) Serum PD-L1 expressions in healthy controls and GBM patients. (C) PD-L1 protein expressions in HA1800 and GBM cell lines. (D) Representative IHC staining images for PD-L1 in human primary GBM tissues and adjacent tissues. Scale bar: original images–200 µ m, enlarged images–50 µ m. (E) ROC curve of IHC immunoreactivity scores of PD-L1 in 80 paraffin primary GBM tissues and 20 adjacent paraffin tissues. (F) Kaplan Meier survival analysis of PD-L1 in TCGA-GBM dataset. Left: Overall survival rate; Right: Disease free survival rate. *P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, ns: no significant.

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