Table 1 Comparison between the mean levels of bio- and haematological markers in moderate and severe cases of COVID-19 patients.

From: Targeting asparagine and cysteine in SARS-CoV-2 variants and human pro-inflammatory mediators to alleviate COVID-19 severity; a cross-section and in-silico study

Clinical- pathological parameters

Moderate (n = 47)

(mean ± SD)

Severe (n = 38)

(mean ± SD)

p value

IL-17(ng/ml)

188.234 ± 61.206

279.5 ± 210.245

0.004*

IL-6(pg/ml)

58.627 ± 83.085

486.02 ± 1048.1

0.006*

Age (years)

57.08 ± 12.8

71.16 ± 9.52

0.0001*

Haemoglobin (g/dl)

12.1 ± 2.3

10.94 ± 2.54

0.030*

RBCs (×106/mm3)

4.42 ± 0.97

3.88 ± 0.84

0.008*

Hct (PCV) (vol %)

34.94 ± 7.22

31.18 ± 7.20

0.019*

RDW (fl.)

12.1 ± 2.303

14.77 ± 4.22

0.048*

MCV(fl.)

79.38 ± 6.16

80.79 ± 7.82

0.356

MCH (pg)

27.638 ± 2.883

28.42 ± 4.03

0.316

MCHC (g/dl)

34.83 ± 1.98

35.18 ± 3.42

0.551

Leukocytes (×103/mm3)

10.54 ± 6.02

13.4 ± 7.73

0.046*

lymphocytes(/µl)

1033.43 ± 729.2

957.84 ± 530.57

0.594

Neutrophils (/µl)

8940.21 ± 5739.5

11892.3 ± 7597.44

0.0444*

Monocytes (/µl)

407.389 ± 308.4

559.07 ± 395.7

0.050*

Platelets (×103/mm3)

245.17 ± 145.71

206.89 ± 140.45

0.2245

MLR(%)

0.504 ± 0.404

0.724 ± 0.689

0.070

NLR(%)

12.302 ± 11.64

16.84 ± 12.6

0.0887

PLR(%)

331.1 ± 275.9

296.45 ± 299.47

0.5810

CRP (mg/L)

133.043 ± 153.5

134.68 ± 139.48

0.9595

Ferritin(ng/ml)

943.568 ± 929.3

945.9 ± 826.58

0.9904

D-dimer (µg/ml)

1.77 ± 2.403

2.63 ± 2.55

0.1142

ALT(U/L)

37.02 ± 32.204

46.815 ± 54.3

0.3046

AST(U/L)

43.78 ± 45.11

53.105 ± 52.17

0.3796

Urea (mg/dl)

86.89 ± 97.76

109.65 ± 90.73

0.2737

Creatinine (mg/dl)

1.43 ± 1.28

2.77 ± 3.12

0.0088*

  1. *Statistically significant at p ≤ 0.05.