Fig. 1

TFRD treatment promoted geometric recovery of newly formed bone in MTD mice. (A) Schematic of MTD development and the TFRD administration strategy. (B) Representative 3D reconstructions of the bone callus in the control and TFRD treatment groups at PSD 8. Quantitative analysis of the (C) BV/TV, (D) Tb.Th, (E) Tb.N and (F) Tb.Sp of the defect region on PSD 8 (n = 6). (G) H&E and Goldner staining of the bone callus on PSD 8 from each group; scale bar = 100 μm. (H) Quantitative analysis of the bone area in the callus on PSD 8; n = 6.