Fig. 4 | Scientific Reports

Fig. 4

From: Total flavonoids of rhizoma drynariae improved the osteogenic and pro-angiogenic capacities of BMSCs to accelerate long bone regeneration

Fig. 4

TFRD enhanced angiogenic‒osteogenic coupling during defect repair in MTD mice. (A) Immunofluorescence images of EMCN (red), PRRX1 (green) and DAPI (blue) in representative thick longitudinal sections across the MTD defect region at PSD 8; scale bar = 200 μm. Quantitative analysis of (B) vessel volume and (C) the number of PRRX1 + cells in the VOI from A (n = 6). (D) Spatial distribution analysis between EMCN + vessels and PRRX1 + osteoprogenitors. Letters “a” indicate a significant difference between TFRD-M and CL, and “b” indicates a significant difference between TFRD-M and TFRD-L (n = 6).

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