Fig. 7 | Scientific Reports

Fig. 7

From: Total flavonoids of rhizoma drynariae improved the osteogenic and pro-angiogenic capacities of BMSCs to accelerate long bone regeneration

Fig. 7

TFRD enhanced HIF-1α signaling by inhibiting endothelial YAP1 expression during MTD repair. (A) Representative fluorescence images of EMCN (red), YAP1 (green) and DAPI (blue) in the callus on PSD 8; color: EMCN + YAP + cells; c: cortical bone. Quantitative analysis of (B) YAP1 volume and (C) EMCN + YAP1 + volume in the callus (n = 6). (D) Representative fluorescence images of EMCN (red), HIF-1α (green) and DAPI (blue) in the callus at PSD 8; color: EMCN + HIF-1α + cells; c: cortical bone. Quantitative analysis of (E) HIF-1α volume and (F) EMCN + HIF-1α + volume in the callus (n = 6). (G) Representative fluorescence images of EMCN (red), VEGFR2 (green) and DAPI (blue) in the callus on PSD 8; color: EMCN + VEGFR2 + cells; c: cortical bone. Quantitative analysis of (H) VEGFR2 volume and (I) EMCN + VEGFR2 + volume in the callus (n = 6).

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