Table 4 Variant titer fold changes from WT (614D/G) per serum group (conv = convalescent). Mean fold drops were calculated from fold drops per study, not from GMT fold drops. Studies reporting fold drops but not GMTs result in a discrepancy between GMT based mean fold drop and individual study based mean fold drop (Table 2). The 95% CI is given in parentheses, the number of data points n in the next line. WT summarizes wild type-like strains (e.g: 614D, 614G).

From: Combining antigenic data from public sources gives an early indication of the immune escape of emerging virus variants

Serum Group

Alpha

Beta

Gamma

Delta

2x Vax

1.3 (1; 1.7)

4.6 (3.8; 5.5)

2.6 (1.6; 4.2)

2.7 (2.3; 3.3)

n=11

n=44

n=7

n=50

3x Vax

1 (0.7; 1.4)

2.6 (2.1; 3.3)

 

2.3 (1.9; 2.6)

n=9

n=30

 

n=33

Inf + Vax

1.7

3.1 (2.2; 4.2)

3.3

1.8 (1.2; 2.8)

n=1

n=12

n=1

n=16

Vax + Inf

1.2 (0; 504.7)

5 (1.3; 18.9)

3.2

1.9 (1.2; 2.9)

n=2

n=3

n=1

n=10

Vax + BA.1

1.1 (0.5; 2.3)

2.2 (1.4; 3.7)

 

1.8 (1.3; 2.5)

n=5

n=10

 

n=15

Vax + BA.2

0.7 (0.7; 0.7)

1.7 (1.7; 1.7)

 

2.1 (0.1; 30)

n=2

n=2

 

n=3

WT conv

2.1 (1.5; 3)

6.1 (3.7; 10)

3.5 (1.2; 10.1)

2.2 (1.7; 2.8)

n=7

n=9

n=4

n=18

Alpha conv

0.6 (0.3; 1)

2.7 (1; 7.4)

2.6 (0.4; 15.4)

1.8 (1.2; 2.8)

n=7

n=6

n=4

n=8

Beta conv

0.8 (0.3; 2.3)

0.3 (0.2; 0.8)

0.4 (0.1; 3.2)

1.5 (0.6; 3.9)

n=5

n=5

n=4

n=6

Gamma conv

0.9 (0.5; 1.6)

0.6 (0.3; 1.2)

0.3 (0.1; 0.9)

2.6 (0.9; 7.6)

n=4

n=4

n=3

n=4

Delta conv

1.1 (0.7; 1.7)

2.7 (1.4; 5)

1.6 (0.3; 7.8)

0.2 (0.1; 0.3)

n=6

n=6

n=4

n=10

BA.1 conv

1.7 (1.1; 2.5)

1.5 (0.8; 2.7)

1 (0; 70)

1.1 (0.8; 1.7)

n=4

n=7

n=2

n=9

BA.2 conv

1.1

1.1

2.4

0.7 (0; 45.1)

n=1

n=1

n=1

n=2

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