Table 3 Results of kinetic models applied to the dissolution data.

From: Characterization and safety evaluation of highly swellable polymeric nanomatrices for enhanced solubility of acyclovir

Kinetic models

pH 1.2 pH 6.8 Water

Parameters

PCD-1 to PCD-9 (mean)

Tab. Acylex®

PCD-1 to PCD-9 (mean)

Tab. Acylex®

PCD-1 to PCD-9 (mean)

Tab. Acylex®

Zero order

R2

0.8283

0.9892

0.8352

0.9823

0.8432

0.9828

T25

38.165

66.526

41.161

78.212

42.032

78.542

T50

77.213

139.421

81.238

159.528

81.785

160.211

T75

118.315

204.161

121.119

238.342

122.045

239.441

First order

R2

0.9831

0.9421

0.9682

0.9464

0.9698

0.9478

T25

16.105

57.256

17.421

69.504

17.982

70.113

T50

40.572

135.215

46.571

165.701

47.023

166.654

T75

83.710

267.373

87.826

331.632

88.031

332.341

Higuchi

R2

0.9421

0.9853

0.9489

0.9873

0.9496

0.9813

Korsmeyer Peppas

R2

0.9398

0.9987

0.9617

0.9968

0.9673

0.9973

N

0.433

0.776

0.759

0.437

0.761

0.439

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