Table 4 Stability studies of the optimized nanomatrices (PCD-6).

From: Characterization and safety evaluation of highly swellable polymeric nanomatrices for enhanced solubility of acyclovir

Sr. No.

Parameters

0 month

3rd month

6th month

1.

Physical appearance

Initially white in color

Nanomatrices were white in color

White color nanomatrices were observed

2.

FTIR spectral arrangement

Performed

Specific spectra were observed at specific wave number

No change or shifting of the peaks was observed. All the specific spectra were present at their specific wave number

3.

Particle size

Performed

Particle size was found to be constant. Zeta potential and PDI were also the same as observed in initial stage of the stability study

No noticeable change was observed in the particle size. Zeta potential and PDI were also found to be same as that of the original values observed at start of the stability studies

4.

Percent drug loading

88.643%

88.513%

88.411%

5.

Swelling ability

Remained constant

No noticeable change was observed in the swelling behavior

No visible change was found