Fig. 1

Analysis of PARIS (ZNF746) orthologs in vertebrates. (A) Phylogenetic distribution of ZNF746 orthologs across vertebrates based on the Ensembl database 19. Pie charts represent the proportion of species with (green) and without (white) ZNF746 orthologs in each vertebrate group. (B) Phylogenetic tree of ZNF746 orthologs based on the Ensembl gene tree 19. Primates and rodents are highlighted with blue and orange backgrounds, respectively. (C) Sequence alignment showing the amino acid sequence of the putative DNA-binding domain of PARIS in humans and mice.