Table 1 SNPs associated with metabolic and non-metabolic traits in or near ZNF746 identified through GWAS studies. Data derived from the GWAS Catalog (https://www.ebi.ac.uk/gwas/), accessed March 20, 2025.

From: PARIS/ZNF746 DNA-binding domain deficiency promotes adipose tissue hyperplasia and hepatic lipid accumulation

riskAllele

p value

Mapped genes

Trait name

Accession ID

rs6972751-?

2.00E-06

ZNF746

General cognitive ability

GCST006269

rs150290553-A

9.00E-06

ZNF746

Apolipoprotein B levels (adjusted for BMI) x vegetarianism interaction

GCST90161208

rs6949316-?

4.00E-08

ZNF746

Triglyceride levels

GCST90239661

rs6972751-T

2.00E-09

ZNF746

Type 2 diabetes

GCST90492734

rs11974139-C

5.00E-11

ZNF746,ZNF777

Monocyte count

GCST90002340

rs855913-A

4.00E-08

ZNF746,ZNF767P

Amyotrophic lateral sclerosis

GCST000406

rs115476423-?

5.00E-06

ZNF746,ZNF767P

Blood pressure traits (multi-trait analysis)

GCST004388

rs62490267-C

5.00E-08

ZNF746,ZNF767P

Type 2 diabetes

GCST010557

rs855917-G

3.00E-08

ZNF767P,ZNF746

Cerebral aneurysm

GCST90013762

rs144738335-T

2.00E-06

ZNF777,ZNF746

Time to colon cancer recurrence

GCST90060090