Fig. 1
From: Protective effect of tanshinone IIA against Listeria monocytogenes infection in vitro and in vivo
Tan IIA suppressed the pore-forming property of LLO. (A) Chemical structure of tanshinone IIA (Tan IIA). (B, C) Inhibitory effects of Tan IIA on the hemolysis of rabbit red blood cell suspension induced by LLO (B) and the cultures of L. monocytogenes wide-type EGD and LLO-deficient mutant EGDΔhly strains (C). Phosphate buffered saline (PBS) and distilled water were included as negative and positive haemolytic controls, respectively. The data were presented as means ± SD (n = 3). **p < 0.01 vs. 0 µg/mL. (D) The growth curve of L. monocytogenes treated with Tan IIA (0–8 µg/mL). (E) The protein expression levels of LLO and isocitrate dehydrogenase (ICDH) in L. monocytogenes treated with Tan IIA (0–8 µg/mL) via Western blotting. The figure shown is representative of three independent experiments.
