Fig. 2

Heterogeneity of CD8+ T cells. (a) UMAP plot showing the clustering of CD8+ T cells into 8 distinct subpopulations. (b) UMAP plot colored according to sample group. (c) UMAP plot annotated with CD8+ T cell subtypes. (d) Violin plots of the expression levels of selected marker genes across the CD8+ T_MT. (e) Average expression of exhaustion-related genes in different groups. (f) Proportion of CD8+ T cell subtypes within each sample group.