Fig. 2
Multidimensional Filtering and Selection of Hedgehog pathway differential genes. (A, B) Weighted gene co-expression network analysis (WGCNA) and differential analysis of Hedgehog pathway differential genes (HH-DEGs) in the ICGC cohort. (C) Venn diagram illustrating the results from WGCNA and differential analysis. (D, E) Random forest and Lasso regression analyses performed on the filtered genes. (F) Venn diagram showing the results from the random forest and Lasso regression analyses. (G) A univariate Cox regression analysis was performed on the seven H-DEGs using data from the ICGC database. (H) Expression levels of COX7B2 and SLC25A39 in the TCGA-HCC cohort. (I) Prognostic assessment of SLC25A39 and COX7B2 from HCC cohorts in TCGA and ICGC. Mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.
