Fig. 3
Effects of UC-MSCs and AD-MSCs on hematological parameters in the systemic hypersensitivity test. (A) New Zealand white rabbits were injected with UC-MSCs or AD-MSCs at doses of 0.125 or 2.5 × 106 cells/kg on days 0, 2, and 4, followed by an additional double dose of 0.25 or 5 × 106 cells/kg on day 14. The control group received injections of Ringer’s lactate. (B-C) The body weights and body temperatures of the injected animals were monitored for 14 days. (D-G) Peripheral blood was collected from the experimental animals 30 min prior to each injection, as indicated in the experimental diagram (A). RBC (D), hemoglobin (E), WBC (F), and platelet (G) levels were measured. (H) Representative images of thrombosis in the lungs of dead rabbits. Data were presented as mean ± SD. p values were determined via t tests (*, p < 0.05, indicated the difference between high and low dose of UC-MSC and #, P < 0.05, indicated the difference between high and low dose of AD-MSC).
