Fig. 4
Effects of MSC injection on allergenic and proinflammatory cytokines in the systemic hypersensitivity test. New Zealand white rabbits (n = 7) were injected with UC-MSCs or AD-MSCs at a dose of 0.125 or 2.5 × 106 cells/kg on days 0, 2, and 4, followed by an additional double dose of 0.25 or 5 × 106 cells/kg on day 14. The group injected with Ringer’s lactate served as the control. (A-F) Plasma was obtained from the experimental animals before injection and after the 1 st, 2nd, 3rd, and 4th injections. The concentrations of plasma histamine (A), IgE (B), IL-6 (C), IL-1β (D), IFN-γ (E), and TNF-α (F) were measured via ELISA. Data were presented as mean ± SD. p values were determined by t tests (#, p < 0.05, indicated a difference at the specified time points in AD-MSC-high group).
