Fig. 8
Organ functions in the subchronic toxicity test of UC-MSCs and AD-MSCs. Wistar rats (n = 6) received intravenous injections of either UC-MSCs or AD-MSCs at low (5 × 106 cells/kg) or high (15 × 106 cells/kg) doses on days 0, 10, and 20. The groups that were injected with Ringer’s lactate or left untreated served as controls. The levels of AST and ALT (A) and urea and creatinine (B) in blood samples that were collected before and after each injection were measured. At the termination of the experiment, 50% of the animals in each group (n = 3) were sacrificed, and the liver, kidney, spleen, and lungs were collected for macroscopic and microscopic observation by H&E staining (C). Scale bars, 100 μm.
