Fig. 5 | Scientific Reports

Fig. 5

From: Vasomotion delineates cerebral vascular dynamic features and participates in the homeostatic cerebral blood flow regulation

Fig. 5

Blebbistatin reduces cerebral blood flow independently of arteriolar diameter. (A) LSCI images of the mouse whole brain indicate the time course changes in the CBF before, Bleb 8 min and Bleb 60 min. Magenta rectangles indicate the analyzed MCA area. (B) Statistical analysis of the relative CBF changes between experiment group (intravenous administration of blebbistatin, N = 3 mice) and control group (the same volume of the vehicle, N = 3 mice) at different time points. (C) Statistical analysis of the relative diameter changes between experiment group (intravenous administration of blebbistatin, n = 20 arterioles segments from 3 mice) at different time points. (D) The cross-correlation analysis between relative MCA blood flow and arteriolar diameter change rate at different time points after intravenous administration of blebbistatin (N = 3 mice). The different color dots represent different time points following blebbistatin administration. Statistics for (B, C), paired t-tests were used.

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