Fig. 5 | Scientific Reports

Fig. 5

From: Rapamycin alleviates hypothalamic injury in exertional heat stroke rats by activating mitophagy through the mTOR/Pink1/Parkin pathway

Fig. 5

Rapamycin upregulated mitophagy in the hypothalamus of rats with EHS. A. Western blot results for LC3 and p62 in rat hypothalamus. B and C. Statistical analysis of the LC3-Ⅱ/LC3-Ⅰ ratio and p62 protein expression in the rat hypothalamus. *P < 0.05 vs. control group, *P < 0.05 vs. EHS group. D. Immunofluorescence co-staining of LC3 and Tom20 in hypothalamic neurons. Bar: 20 μm. RAPA group(n = 10): Normal rats injected with rapamycin, EHS(n = 5): Exertional heat stroke model group, EHS + RAPA group(n = 8): Rapamycin-injected model group.

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