Fig. 2 | Scientific Reports

Fig. 2

From: Comprehensive analysis of microRNA expression provides mechanistic insights into transcriptomic alteration in primary and metastatic testicular germ cell tumors

Fig. 2

Differential expression analysis between pairs of histology groups reveals well-known and novel miRNA markers in TGCT. (A–C) Volcano plot showing the log2 fold-change (x-axis) between SEM and teratoma (A), N-SEM and teratoma (B), and SEM and N-SEM (C), and the −log10 p-value of corresponding differential analysis. Differentially expressed miRNAs were identified by Bonferroni-adjusted p < 0.05 with log2 fold-change > 2. Previously described miRNAs implicated in TGCT (miR-371a-3p, miR-372, miR-373, miR-367) were labeled, as did miR-200b-3p in (C). Colors indicate miRNAs differentially expressed in each tumor type in each pairwise comparison. (D–F) Receiver operating curves for distinguishing histology group pairs ((D) SEM vs. teratoma, (E) N-SEM vs. teratoma, (F) SEM vs. N-SEM), using only the previously described markers and the top 5 most differentially expressed miRNAs identified in our study (see Supplementary Table 2 for details). AUC: area under the receiver-operating curve.

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