Fig. 1
From: Tacrolimus modulates the PI3K AKT mTOR pathway in retinal epithelial cells under inflammatory stress
Venn diagram illustrating the overlap and time-specific distribution of differentially expressed mRNAs (|FC| > 4.0, p < 0.05) associated with the PI3K/AKT/mTOR signaling pathway in LPS-treated H-RPE cells following tacrolimus exposure. H_6, H_12, and H_24 indicate cells harvested after 6, 12, and 24 h of tacrolimus treatment, respectively; C represents untreated control cells. Genes abbreviation: CDK2, Cyclin-Dependent Kinase 2; CDK4, Cyclin-Dependent Kinase 4; COL6A2, Collagen Type VI Alpha 2 Chain; COL6A3, Collagen Type VI Alpha 3 Chain; WNT1, Wnt Family Member 1; WNT4, Wnt Family Member 4; JAK1, Janus Kinase 1; JAK3, Janus Kinase 3; STAT3, Signal Transducer and Activator of Transcription 3; EGFR, Epidermal Growth Factor Receptor; PIK3CA, Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha; PIK3CB, Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta; PIK3CD, Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta; PIK3CG, Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma; IL-6, Interleukin 6; IL6R, Interleukin 6 Receptor; RHOA, Ras Homolog Family Member A; TLR2, Toll-Like Receptor 2; TLR4, Toll-Like Receptor 4; FZD5, Frizzled Class Receptor 5; IL-2, Interleukin 2; MTOR, Mechanistic Target of Rapamycin Kinase; MAP2K2, Mitogen-Activated Protein Kinase Kinase 2; COL1A1, Collagen Type I Alpha 1 Chain; COL1A2, Collagen Type I Alpha 2 Chain; BDNF, Brain-Derived Neurotrophic Factor.
