Table 2 Microarray profile of PI3K/AKT/mTOR signaling pathway–dependent genes in H-RPE cultures exposed to LPS, tacrolimus, or their combination (|FC| > 4.00 in any comparison; all listed mRNAs are statistically significant, p < 0.05).
From: Tacrolimus modulates the PI3K AKT mTOR pathway in retinal epithelial cells under inflammatory stress
Probeset ID | mRNA | LPS | Tacrolimus | LPS + tacrolimus | ||
|---|---|---|---|---|---|---|
log2 fold change | ||||||
H_6 vs. C | H_6 vs. C | H_6 vs. C | H_12 vs. C | H_24 vs. C | ||
204252_at | CDK2 | + 4.34 | -2.75 | + 4.13 | + 2.81 | + 2.99 |
211803_at | + 4.32 | -2.87 | + 4.32 | + 2.91 | + 3.12 | |
211804_s_at | + 4.16 | -3.10 | + 4.18 | + 2.77 | + 2.76 | |
202246_s_at | CDK4 | + 3.47 | -3.45 | + 4.98 | + 4.12 | + 3.11 |
209156_s_at | COL6A2 | + 4.56 | + 2.11 | + 2.87 | -3.34 | -4.48 |
213290_at | + 4.61 | + 2.81 | + 2.98 | -3.31 | -4.77 | |
201438_at | COL6A3 | + 4.16 | + 2.98 | -3.24 | -4.01 | -4.12 |
208570_at | WNT1 | + 2.98 | + 1.98 | -5.43 | -2.34 | -2.37 |
208606_s_at | WNT4 | + 3.12 | + 2.34 | -4.32 | -2.34 | -2.34 |
230751_at | + 3.45 | + 2.81 | -4.56 | -2.65 | -2.87 | |
1556689_a_at | + 2.91 | + 2.09 | -4.91 | -2.98 | -2.17 | |
201648_at | JAK1 | + 3.45 | + 3.21 | + 3.44 | -2.99 | + 5.45 |
239695_at | + 3.21 | + 3.32 | + 3.42 | -3.21 | + 4.98 | |
240613_at | + 3.61 | + 3.09 | + 3.56 | -3.12 | + 5.61 | |
1552610_a_at | + 3.71 | + 3.81 | + 4.01 | -2.76 | + 5.43 | |
1552611_a_at | + 3.63 | + 315 | + 3.87 | -2.81 | + 5.87 | |
207187_at | JAK3 | + 2.54 | + 3.18 | + 3.98 | + 4.85 | + 5.63 |
211108_s_at | + 2.61 | + 2.99 | + 4.14 | + 5.12 | + 5.76 | |
211109_at | + 2.83 | + 3.65 | + 4.16 | + 4.91 | + 6.01 | |
227677_at | + 2.81 | + 3.61 | + 3.99 | + 4.98 | + 5.43 | |
208991_at | STAT3 | + 3.41 | + 2.12 | -3.45 | -4.11 | -4.09 |
208992_s_at | + 3.71 | + 2.87 | -3.71 | -4.32 | -4.32 | |
225289_at | + 3.18 | + 2.51 | -3.56 | -4.87 | -4.51 | |
+ 3.65 | + 2.71 | -3.81 | -4.23 | -4.74 | ||
201983_s_at | EGFR | + 4.17 | + 1.19 | -2.34 | -4.56 | -4.32 |
201984_s_at | + 4.51 | + 1.87 | -2.65 | -4.32 | -4.76 | |
210984_x_at | + 4.32 | + 1.34 | -2.43 | -4.61 | -4.89 | |
211550_at | + 4.55 | + 1.44 | -2.71 | -5.12 | -4.71 | |
211551_at | + 4.16 | + 1.11 | -2.45 | -4.78 | -4.88 | |
211607_x_at | + 4.71 | + 1.16 | -2.55 | -4.34 | -4.91 | |
224999_at | + 4.61 | + 1.21 | -2.87 | -4.54 | -4.76 | |
1565483_at | + 4.74 | + 1.19 | -2.19 | -4.43 | -4.53 | |
1565484_x_at | + 4.18 | + 1.16 | -2.97 | -4.67 | -4.71 | |
204369_at | PIK3CA | + 5.67 | + 2.65 | -5.60 | -5.87 | -5.12 |
231854_at | + 5.93 | + 2.51 | -5.17 | -5.43 | -5.43 | |
235980_at | + 5.44 | + 2.76 | -5.87 | -5.67 | -5.61 | |
212688_at | PIK3CB | + 5.42 | -3.45 | -4.13 | -4.35 | -4.78 |
217620_s_at | + 5.76 | -3.16 | -4.61 | -4.86 | -4.56 | |
203879_at | PIK3CD | + 4.17 | -3.18 | -5.67 | -4.12 | -4.91 |
211230_s_at | + 4.51 | -3.71 | -6.19 | -4.25 | -5.02 | |
206369_s_at | PIK3CG | + 4.98 | -2.11 | -3.87 | -4.51 | -4.65 |
206370_at | + 5.17 | -2.23 | -4.15 | -4.16 | -4.77 | |
205207_at | IL-6 | -3.12 | + 5.13 | + 5.23 | + 4.62 | -3.17 |
205945_at | IL6R | + 3.71 | -2.25 | -4.87 | -4.12 | -3.31 |
217489_s_at | + 3.17 | -2.17 | -5.41 | -4.41 | -3.45 | |
226333_at | + 4.01 | -2.65 | -4.81 | -4.22 | -3.41 | |
200059_s_at | RHOA | + 2.13 | -1.56 | -4.12 | -3.54 | -3.12 |
240337_at | + 2.35 | -1.61 | -4.65 | -3.67 | -2.76 | |
1555814_a_at | + 2.81 | -1.74 | -4.87 | -3.61 | -3.45 | |
204924_at | TLR2 | + 6.17 | -2.34 | -4.56 | -5.43 | -5.21 |
221060_s_at | TLR4 | + 5.45 | -2.13 | -5.43 | -5.66 | -4.87 |
224341_x_at | + 5.17 | -2.17 | -5.43 | -5.62 | -4.56 | |
232068_s_at | + 5.74 | -2.32 | -4.98 | -5.44 | -4.99 | |
1552798_a_at | + 5.26 | -2.01 | -5.23 | -5.87 | -4.72 | |
206136_at | FZD5 | + 3.42 | + 1.98 | -4.01 | -3.45 | -2.12 |
221245_s_at | + 3.16 | + 2.01 | -3.46 | -4.01 | -2.13 | |
207849_at | IL-2 | + 1.11 | + 4.17 | + 3.69 | + 5.41 | + 4.12 |
202288_at | MTOR | + 2.11 | + 2.01 | -4.17 | -2.21 | -1.87 |
215381_at | + 2.76 | + 2.13 | -4.32 | -2.34 | -2.01 | |
202424_at | MAP2K2 | + 4.98 | + 2.18 | -3.49 | -4.99 | -4.32 |
213487_at | + 4.61 | + 2.13 | -3.76 | -4.12 | -4.56 | |
213490_s_at | + 5.18 | + 2.34 | -3.81 | -5.16 | -4.61 | |
202310_s_at | COL1A1 | + 4.71 | + 2.18 | -4.32 | -4.19 | -3.41 |
202311_s_at | + 4.51 | + 2.16 | -4.56 | -4.52 | -3.54 | |
202312_s_at | + 4.99 | + 2.56 | -4.23 | -4.87 | -3.66 | |
217430_x_at | + 4.16 | + 2.61 | -4.71 | -4.68 | -3.18 | |
1556499_s_at | + 4.64 | + 2.47 | -4.41 | -4.17 | -3.81 | |
202403_s_at | COL1A2 | + 5.67 | + 1.98 | -4.11 | -3.87 | -2.18 |
202404_s_at | + 5.81 | + 2.17 | -4.32 | -3.91 | -2.12 | |
229218_at | + 5.17 | + 2.03 | -4.87 | -4.01 | -2.81 | |
206382_s_at | BDNF | + 2.34 | + 2.89 | + 4.51 | + 4.09 | + 2.12 |
239367_at | + 2.12 | + 2.99 | + 4.44 | + 4.13 | + 2.34 | |
