Fig. 11 | Scientific Reports

Fig. 11

From: Integration of single-cell and bulk RNA sequencing data to identify liquid–liquid phase separation-related prognostic biomarkers in hepatocellular carcinoma

Fig. 11

Validation of the expression of risk signature genes at single-cell and transcriptomic levels. (A) Expression of ENO1, G6PD, GOT2, HAGH, HSPD1, KLF4, LGALS3, MARCKSL1, RANBP1, and TARS in HCC tumor and normal tissues in the GSE14520 cohort. (B) Kaplan-Meier survival curves based on high and low expression of the signature genes in the TCGA-LIHC cohort. (C) ROC curves showing the AUC for predicting OS at 1, 3, and 5 years in the TCGA-LIHC cohort. (D) UMAP plots of the expression of the signature genes in different cell types. (E) Prognostic gene-protein interaction network based on GeneMANIA. (F) Functional similarity analysis by GOSemSim.

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