Fig. 4

Interactions between malignant hepatocytes and other cell populations. (A) Number of interactions in the cell-cell communication network between malignant hepatocytes and other cell types. (B) Circle plots illustrating the intensity of outgoing interactions from malignant and non-malignant hepatocytes to other cell types. (C) Heatmap showing enriched signaling interaction intensities between hepatocytes and other cell types. (D) Number of interactions in the cell-cell communication network between hepatocytes with high-LLPS and low-LLPS scores. (E) Circle plots depicting the intensity of outgoing interactions from high-LLPS and low-LLPS score hepatocytes to other cell types. (F) Heatmap of enriched outgoing signaling interaction intensities for high-LLPS and low-LLPS score hepatocytes with other cell types. (G) Dot plots displaying enriched outgoing ligand-receptor interaction intensities for high-LLPS and low-LLPS score hepatocytes with other cell types. (H) Cell-cell communication hierarchy diagram in the EGF and MIF signaling pathways. Solid circles and hollow circles represent source cells and target cells, respectively. The size of each circle represents proportional to the number of cells in each group, and the thickness of the lines indicates the strength of the interaction signals. In the left panel, the “target” in the center represents the selected target cells, while the right panel shows another group of cells selected as target cells, with their interactions observed by placing them in the center.